Textfeld:  Center for Clinical Epidemiology and Longitudinal Studies (CELOS)



Prof. Dr. Katja Beesdo-Baum, Dr. Lars Pieper,

Dr. Michael Höfler, Prof. Dr. Hans-Ulrich Wittchen


Mission: To facilitate, promote and to conduct clinical and behavioural epidemiological studies with particular focus on longitudinal and family genetic studies in the community, primary care and clinical cohorts.

- To provide and develop state of the art methods for use in clinical epidemiological and longitudinal research including survey and laboratory-based assessment techniques and diagnostic tools.

- To provide biometric and statistical expertise with particular focus on causal-analytic statistical methods within complex designs.

- To provide state of the art expertise in sampling, survey methodology and field work procedures, data collection and data bank management.


The Center for Clinical Epidemiology and Longitudinal Studies (CELOS) is a laboratory platform of the Institute of Clinical Psychology and Psychotherapy in the Faculty of Mathematics and Natural Sciences, located on 156 sqm (6 rooms, adjacent to the Institute). It includes field work-, CATI- and CAPI-administration labs. With the appointment of a new chair of behavioural epidemiology in spring 2014 (Prof. Dr. K. Beesdo-Baum) and the Funding of a new epidemiological cohort study (BMBF), the laboratory platform will be supplemented by new behavioural observation and experimental labs. The CELOS center has extensive experience in the management of large-scale data banks and multi-center longitudinal data sets (comprising genetic, endocrine, clinical and experimental data with thousands of subjects). Concerning the statistical data processing there is excellent expertise in sampling theory and weighting procedure, as well as statistical expertise, particularly with regard to modeling causal pathways, psychometric analyses, sensitivity and specificity analyses and complex multivariate statistics.


CELOS survey lab

The survey lab is part of the CELOS centre. Its purpose is the field work and computer-assisted telephone interviewing.It consists of 10 workstations in two rooms. Each work station is separated by partition panels and equipped with a telephone (with headset) connected via USB to a desktop PC or Laptop. Phones are completely controlled by PC, therefore hand-free calling is possible. Calling and data entry runs with a Microsoft Access application. Collected data can be exported in several fileformats and further data processing with standard statistical software (Stata) is possible.

&xnbsp;&xnbsp;&xnbsp;&xnbsp; Computer Assisted Personal Interview&xnbsp; &xnbsp;&xnbsp;&xnbsp;&xnbsp;&xnbsp;&xnbsp;&xnbsp;&xnbsp;&xnbsp;&xnbsp;&xnbsp;Computerized questionnaires&xnbsp;&xnbsp;&xnbsp;&xnbsp;&xnbsp;&xnbsp;&xnbsp;&xnbsp;&xnbsp;&xnbsp;&xnbsp;&xnbsp;&xnbsp;&xnbsp;&xnbsp;&xnbsp;&xnbsp;&xnbsp;&xnbsp;&xnbsp;&xnbsp; Use of mobile devices

(b) Phone data base and direct data entry

Assessment Unit

Diagnostic tools and psychometrics: Dr. Lars Pieper, Prof. Dr. Hans-Ulrich Wittchen, Prof. Dr. Katja Beesdo-Baum, Dr. Susanne Knappe, Dipl.-Psych. Eva Asselmann

Computer assisted interviewing (CAPI, CATI): Dipl.-Math. Jens Strehle

Survey Lab (CATI): Dr. Lars Pieper

EMA: Dr. Lars Pieper


Biometrics, Statistics, Data Bank Management

Causal analytic designs and methods: Dr. Dipl.-Stat. Michael Höfler

Biometrical and statistical issues: Dr. Dipl.-Stat. Michael Höfler, Dipl.-Math. Jens Strehle, M.Sc.-Math. John Venz

E-CRF, databank management, informatics: Dipl.-Stat. Jens Strehle, Dipl.-Ing. Eckhard Schulz; Torsten Tille

Collaboration with the KKS Dresden


Monitoring: Dr. Lars Pieper; Quality Assurance: 3P Consulting, PD Dr. David Pittrow


Current and past Projects

-National Survey on Health Care of Depression in German Primary Care Practices, ongoing since 2014: >250 physicians, >3000 patients (cross-sectional), >1000 patients longitudinal (3 times, over 1 year); Funding: Federal Ministry of Health

-DfG Research Group “Learning and habitisation as predictors of the Development and Maintenance of Alcoholism”, Z-Project, n=1200 subjects in Dresden and Berlin, cross-sectional and longitudinal; Funding: DFG

-       Alcohol dependence in primary care in Europe (APC), 2400 patients in German primary care, 1500 personal interviews, cross-sectional and longitudinal; Funding: Lundbeck GmbH

-       German Epidemiologic Health Survey (Deutscher epidemiologischer Gesundheitssurvey) DEGS - Zusatzsurvey psychische Gesundheit, 5000 subjects in 120 sample points, personal interviewing; Funding: BMBF

-       Trauma and Stress-related disorders in German Soldiers with and without Foreign Deployment, n=1600 soldiers, cross-sectional and longitudinal; Funding: BMVg

-       Prevalence, 1-year incidence and symptom severity of mental disorders in the elderly: Relationship to impairment, functioning (ICF) and service utilisation (MentDis65+); Funding: EU

-       DSM-5 dimensional measures for depression and anxiety. N=250, cross-sectional study

-       PanicNet: Improving CBT for panic by identifying the active ingredients and understanding the mechanisms of action – a multicenter study. 400 subjects, longitudinal; Funding: BMBF

-       Predictors, Moderators and Outcomes of Substitution Treatment (PREMOS), 2.694 patients; Funding: BMBF.

-       Improving Alzheimer Dementia Treatment: Epidemiological Appraisal of Doctors, Patients and Caregivers Unmet Needs (IDEA), N=500 physicians and N=2.500 patients; Funding: Novartis GmbH

-       The German National Health Interview and Examination Survey - Mental health supplement (BGS): 1998-2005, N=4.181; Funding: BMBF

-       EDSP family genetic program (EDSP-FG, 1998-2005, N=2.100; Funding BMBF and NGF

-       Allocation in Substitution Treatments (COBRA/ASAT): 2002-present, 2.546 patients, 2 waves; Funding: Schering-Plough, BMBF/BMG

-       Smoking and Nicotine Dependence Awareness Study (SNICAS): 2001-2006, 28.000 patients, 813 primary care sites; Funding: GSK and BMBF

-       Depression 2000 and GAD-P: 2000-2005, 35.000 patients in over 800 primary care sites; Funding: Organon, Wyeth

-       Renocardial Syndrome RCS - heart and kidney in patients in dialysis facilities - A nationwide clinical epidemiological cross-sectional study in dialysis facilities: N=200 physicians and N=1000 patients; Funding: Abbott GmbH

-       Severe Asthma: Prevalence and Current Treatment Needs (SAP-Needs), phase I: N=681 physicians and N=13,066 patients, phase II: N=157 physicians and N=570 patients; Funding: Novartis GmbH

-       Multiple Sclerosis Patients and their Caregivers Psychopathological and General Burden of Disease (MS Caregiver Burden), structured interview of N=400 multiple sclerosis patients and 400 care givers; Funding: Norvartis GmbH

-       Expert Based Survey to Investigate the Health Care Situation of Patients with Multiple Sclerosis (MS-Expert), N=2.000 multiple sclerosis healthcare provider, mail and telephone survey; Funding: Novartis GmbH

-       Diabetes Cardiovascular Risk-Evaluation: Targets and Essential Data for Commitment of Treatment (DETECT): 2003-present, N=55.000, 3.795 primary care sites, 3 waves; Funding: Pfizer GmbH

-       Hypertension and Diabetes Risk Screening and Awareness Study (HYDRA): 2001-2006, N=43.000, 1912 primary care Settings; Funding: Sanofi Aventis GmbH